Chapter 536
My Life Simulator Chapter 536
2021-10-14
Chapter 535 The terminal illness that plagues human beings, one lessHigh-precision laser processing technology has achieved success.
Putting aside those great strategic significance, the reducer bottleneck no longer exists purely in robotics.
Next, Lu Li intends to overcome another difficulty - the servo motor.
However...the world is unpredictable.
Just as Lu Li was about to invest in the research of servo motors, he unexpectedly learned a piece of news, which forced Lu Li to change his research direction.
In the evening, Lu Li returned to Fudan's dormitory and finished dinner with Liu Qin.
"Lu Li, do you remember Wang Yan?"
Liu Qin took a chopstick for Lu Li and looked up towards Lu Li.
"Wang Yan?"
Lu Li pondered for a while, and his strong memory immediately allowed Lu Li to dig out the past memory from the depths of his memory.
Wang Yan, Lu Li's high school classmate.
When Yucheng No.1 Middle School, Wang Yan was still Liu Qin's roommate.
"Wang Yan, old classmate!"
Lu Li laughed and said to Liu Qin: "Back then, when I was in Yucheng No. 1 Middle School, Wang Yan was still at the same table as you. What, suddenly mentioning Wang Yan today?"
"Wang Yan..."
Liu Qin sighed, "She is ill, terminally ill! She talked to me this morning. I'm crying like a rustling sound on the phone. I'm also very uncomfortable."
"Sick? What's wrong?"
Lu Li put down his chopsticks and asked Liu Qin stand up.
“Aizi!”
Liu Qin sighed and looked the head, “She found a boyfriend, and the result…”
“So it was ."
Lu Li also sighed and said to Liu Qin: "Wang Yan called you because she wanted to ask me for help?"
It's not hard to guess.
Lu Li is a genetic scientist who is cream of the crop in the world today, and has also made major scientific achievements in overcoming cancer in the medical field.
If anyone could possibly conquer AIDS, perhaps only Lu Li could do it.
Wang Yan found Liu Qin and wanted to ask Lu Li for help. This is such is human nature.
"Wang Yan must have wanted to ask for your help."
Liu Qin nodded, and said to Lu Li: "Lu Li, Wang Yan...it's very pitiful, if you can Help, you can help her! Besides, conquering AIDS is also a major scientific research achievement!"
"You have such confidence in me?"
Lu Li smiled Get up, "AIDS, this is one of the five terminal diseases in the world. Do you think I can find a cure for AIDS in a short time?"
"I definitely have confidence in you!"
A smile appeared on Liu Qin's face, "You are a genetic scientist who is the cream of the crop in the whole world. If you can't do it, no one can do it."
" haha! I love hearing this!"
Lu Li laughed, "Okay! I'll put the project in my hand first, and turn to study the treatment plan for AIDS!"
"Thank you! I thank you for Wang Yan!"
Liu Qin was full of joy, and quickly took out the phone and dialed Wang Yan. After the call was connected, Liu Qin said to Wang Yan, "Wang Yan, I told Lu Li. He will find a way to help you."
"Thank you!" On the phone, Wang Yan was sobbing.
......
On the second day, Lu Li came to the laboratory of Fudan Medical College again.
In the laboratory, Ms. Wen Wan and other graduate students are still working on the human genetic testing project, and the results are already not far away.
Lu Li didn't bother them either, turned around and went to another laboratory, ready to study HIV.
HIV, which is a retrovirus, mainly invades T cells in the human immune system, thereby destroying the human immune system.
This is a typical virus intrusion pattern.
HIV invades T cells, and then transcribes and replicates in T cells to generate countless HIV, which spreads in a large area, kills T cells in a large area, and completely destroys the human immune system.
At present, according to the WHO report, there are nearly 40 million AIDS patients in the world, 2.7 million new infections every year, and 2 million people die of AIDS every year. million people infected with AIDS.
In my country, there are nearly one million AIDS patients, covering all provinces, municipalities and autonomous regions in the country.
AIDS is very dangerous. To date, there is still no real cure.
This time, because of Wang Yan's incident, Lu Li devoted himself to the research on the treatment of AIDS.
In fact, this is not only for Wang Yan, but also a major scientific research benefiting the whole world.
In the lab.
Lu Li was sitting in front of the test bench, carefully observing the process of HIV invading T cells through an electronic Microscope.
On the screen, HIV invades the nucleus and breaks down into RNA gene transcription information.
Immediately, this HIV gene transcription information is quickly combined with the DNA molecular chain in the T cell. The gene transcription mechanism is deceived, so that the DNA transcription mechanism generates HIV DNA molecules according to the transcription information.
It is constantly transcribed, and the HIV DNA molecule is constantly generated. Until the entire T cell is filled with HIV.
By this point, the T cells are dead and all nutrients are used to generate HIV.
Next, thousands of HIV oozes from the dead T cells, spreading continuously, and invading other T cells like crazy.
This is the mechanism of HIV infection.
In fact, the infection mechanism of all viruses is exactly the same as this one. They combine the genetic information of the virus with the DNA of the cell, continuously replicate, constantly generate new viruses, and constantly invade other cells.
For T cells, Lu Li has done a lot of research.
When he was researching cancer treatment programs, the CAR-T anti-cancer technology developed by Lu Li used the immune function of T cells to kill cancer cells.
Nowadays, on AIDS, the weapon that Lu Li used at the beginning has become the target of virus attack.
To treat AIDS, Lu Li still starts with genetics.
In today's world, all HIV treatment programs are unsuccessful, at least not completely curable.
From the perspective of genetics, Lu Li has already thought of the solution to HIV, and it is also a method that already exists in nature.
In nature, a war that has lasted for hundreds of millions of years is breaking out all the time, just around us.
This is the war between bacteria and viruses.
When viruses invade bacteria, it is no different from invading human cells. It also transcribes the gene information of the virus and combines it with the DNA molecules of bacteria.
In the billion-year war between viruses and bacteria, bacteria have evolved a defense mechanism to fight viruses.
This gene sequence called "CRISPR" is a repetitive sequence in the genome of prokaryotes. It is an immune weapon produced by bacteria and viruses in the history of life evolution.
Simply put, bacteria evolved the CRISPR-Cas9 system in order to remove the foreign invasion genes of viruses. Using this system, bacteria can quietly excise viral genes from their own genomes, which is a unique immune system for bacteria.
In fact, the gene editing technology in the world today is based on this CRISPR-Cas9system, the researched gene cutting technology.
Now, Lu Li's idea is to use the CRISPR-Cas9system to arm T cells.
Once HIV invades T cells, it will be cut off by CRISPR-Cas9system to prevent HIV infection.
If successful, the technology could lead to a vaccine against HIV infection.
Of course, the technology still has adequate therapeutic effects for patients already infected with HIV.
The T cells in the human immune system can continuously replicate and proliferate. If the newly born T cells all have the ability to fight against HIV, then... even if HIV kills all the original T cells, it cannot invade the newly born T cells.
In this way, HIV cannot destroy the body's immune system. The surviving HIV will also keep invading new T cells because of the virus, and will be cut off by the CRISPR-Cas9 system constantly, and eventually all die.
Theoretically, this idea is achievable.
Now we will see if the experiment can be successfully completed and whether this CRISPR-Cas9system can be equipped into T cells.
"Open the virtual laboratory!"
Lu Li opened the virtual laboratory with a thought, preparing to do research in the virtual laboratory.
"Virtual AIDS patient."
Lu Li is going to do human genetic experiments directly. This kind of experiment is not easy to do in reality, but it is very convenient to do it in a virtual laboratory.
After imagining an AIDS patient, Lu Li picked up the syringe and took a sample of hematopoietic stem cells from the patient's spinal cord.
T cells in the human immune system are transformed from hematopoietic stem cells under the induction of thymic hormones.
What Lu Li is doing now is to equip the CRISPR-Cas9 system when hematopoietic stem cells are transformed into T cells, so that the newly generated T cells have cellular immune function.
It is not difficult to equip cells with CRISPR-Cas9system.
When doing gene editing, it is necessary to inject CRISPR-Cas9 splicing protein into the cells that need to be spliced and edited.
The real difficulty lies in how to make the hematopoietic stem cells produced in the spinal cord automatically generate immune T cells according to a new template during the process of transforming them into T cells.
This again involves RNA gene transcription information.
Lu Li must also express the armed T cell genes in the form of RNA gene transcription information, so that hematopoietic stem cells can replicate according to this new template.
Fortunately, with Lu Li's current genetic knowledge, it is not difficult to do this.
Next, Lu Li extracted the gene information target of AIDS, added it to the gene target of the CRISPR-Cas9 cleavage protein, and then injected it into the T cell, combined with the DNA molecular chain of the T cell, and then Transcriptase is then injected to generate new gene transcription information.
The newly generated gene transcription information is extracted, injected into hematopoietic stem cells, and combined with the DNA molecular chain of hematopoietic stem cells.
So...In hematopoietic stem cells, according to the new gene transcription information, new DNA molecular chains start to be generated to generate new immune T cells.
At this step, 90% of the experimental process has been completed, and the next step is to see the real treatment effect.
Lu Li cultivated hundreds of millions of hematopoietic stem cells, reinjected them into the patient's body, and transformed them into new armed T cells through the thymus.
After waiting for several hours, Lu Li drew lymph from the patient for testing.
It turns out that...the newly generated T cells with CRISPR-Cas9system have appeared in large numbers.
In these T cells equipped with CRISPR-Cas9system, the viral gene information of HIV invasion is all targeted by the CRISPR-Cas9system target information, which directly shortens the genetic information of HIV and kills it smoothly. had an HIV.
The immune system is constantly generating new T cells. These new T cells are all new T cells equipped with the CRISPR-Cas9system, all of which can kill the invading HIV virus.
After a round of replacement of T cells in the patient's body, once HIV invades the new T cells, it will be destroyed one by one, and eventually disappear completely.
This process... lasts about one to three months, and within six months at most, HIV will be completely killed.
Of course, HIV in these patients is still highly contagious until they are completely cured.
It took two weeks in reality and more than four months in the virtual lab. This virtual AIDS patient was completely cured.
Lu Li conducted a detailed test on this virtual patient, and the presence of HIV was no longer found in the patient's body.
The experiment was successful!
Next, Lu Li repeated the genetic experiment in reality. Human experiments have yet to be done in reality.
After repeating the gene experiment in reality, the following time is the time to write a paper and pretend to be forceful.
“An AIDS treatment program based on CRISPR-Cas9 technology.”
In this paper, Lu Li wrote all the theoretical expressions of CRISPR-Cas9 technology, Theoretically demonstrated the feasibility of using CRISPR-Cas9 technology to edit and modify T cells for the treatment of AIDS.
Of course, in this paper for public publication, there is naturally no detailed experimental data and no detailed operation steps. It is only a theoretical demonstration.
Another technical information with detailed data and experimental steps was sent directly to the Institute of Medicine, Chinese Academy of Sciences by Lu Li.
The published papers are submitted to the international authoritative medical journal "The Lancet", and the papers are also posted on the academic network.
So...Professor Lu name shakes the whole world again.
"Omg! Professor Lu has developed a treatment plan for AIDS!"
"Has Professor Lu finally remembered that he is a medical scientist?"
"The great medical scientist who conquered cancer has conquered AIDS."
"This is a great achievement! Tens of millions of AIDS patients around the world have ushered in their salvation."
"Is AIDS no longer bothering mankind? This is really good news."
"Professor Lu is the Nobel Prize in Medicine. No one is eligible to receive the Nobel Prize in Medicine except him."
“There is one less terminal illness that plagues mankind. Even the most demanding person must admit that Professor Lu is the greatest scientist in the world.”
The scientific and medical communities have Lu Li expressed his warm appreciation for his achievements in overcoming AIDS.
Even... foreign media are all advocating it.
Professor Lu has such a high innate talent in medicine, of course, he should focus on medical research for the benefit of all mankind. Don't be distracted by other science and technology.
(end of this chapter)